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从骨髓释放的循环血内皮前体细胞(EPCs)具有内分泌、血管内皮修复和血管再生功能,对动脉粥样硬化的发生、发展起重要作用。然而,循环内皮前体细胞的数量和功能在心血管疾病患者中明显下降。这些细胞的数量和功能不仅受许多生理和病理因素的影响,包括衰老、糖尿病、高血压、高血脂等;也与个人的生活方式,如:运动、体质量、吸烟等心血管疾病危险因子密切相关。本文着重讨论循环血内皮前体细胞的功能及影响因素,并对其在心血管疾病中的临床应用前景作一展望。
Circulating blood endothelial progenitor cells (EPCs) released from bone marrow have the functions of endocrine, endothelium repair and blood vessel regeneration and play an important role in the development of atherosclerosis. However, the number and function of circulating endothelial progenitor cells is significantly reduced in patients with cardiovascular disease. The number and function of these cells are affected not only by a number of physiological and pathological factors, including aging, diabetes, hypertension, hyperlipidemia, but also with cardiovascular risk factors such as exercise, body weight, smoking and other lifestyle factors Related. This article focuses on the function of circulating endothelial progenitor cells and its influencing factors and prospects for its clinical application in cardiovascular disease.