哮喘认识的更新

• 作 者: 黄茂
• 出 处: 国外医学.呼吸系统分册
• 发表日期: 1990年04期
• 关键词: 慢性炎症疾病 细胞相互作用 支气管高反应性 神经反射 支气管收缩 粘膜水肿 肌收缩 炎症介质 支气管反应性 胆碱能神经

哮喘曾被简单地认为是过敏原引起肥大细胞脱颗粒,释放介质,而使气道乎滑肌收缩所致,现已明了哮喘是一种涉及多种细胞相互作用的一种慢性炎症疾病.这些细胞释放大量炎性介质,激活气道靶细胞,引起支气管痉挛、微血管渗漏、粘膜水肿、粘液分泌亢进和神经反射兴奋,似可能有几种不同类型的哮喘涉及不同的发生机理,对几种治疗方法需进行更多的研究.

Asthma has been briefly considered as an allergen that causes mast cells to degranulate and release mediators resulting in contractions of the airway smooth muscle. It has become clear that asthma is a chronic inflammatory disease involving a variety of cell-cell interactions. These Cells release large amounts of inflammatory mediators, activate airway target cells, cause bronchospasm, microvascular leakage, mucosal edema, hypersecretion of mucus and excitement of reflexes. It may seem that several different types of asthma involve different mechanisms of pathogenesis, The treatment needs more research.