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以往通过对大鼠血和尿中砷的代谢产物的研究,已阐明大鼠摄入无机砷后在其体内可转化为4种不同形态的代谢产物,即三价砷、五价砷、甲胂酸(MAA)和二甲肿酸(DMAA)等。本文进一步报导了三氧化二砷经口投与大鼠后在脏器、组织、血液、尿和粪中转化为上述4种不同形态砷的代谢情况。实验动物用体重为250～800克的Wistar系雄性大鼠,每组5只,以20毫克As/公斤体重剂量的三氧化二砷(纯度为99.9％)溶液一次灌胃。给药后30分钟、1、6小时及1、2、3、7、10、30、60和120天后,分别测定大鼠脏器、组织、血液、尿和粪中4种形态砷代谢物的含量,结果如下: 1.血液中三氧化二砷的代谢产物血液中总砷浓度,在给药后6小时急剧上升,两天后达最高值,为对照组的200倍,120天后仍此
In the past through the rat blood and urinary arsenic metabolites, studies have shown that ingestion of inorganic arsenic in rats after its body can be transformed into four different forms of metabolites, namely trivalent arsenic, pentavalent arsenic, arsine Acid (MAA) and dimethic acid (DMAA) and so on. This article further reports the metabolism of arsenic trioxide into four different forms of arsenic in organs, tissues, blood, urine and feces after oral administration of arsenic trioxide. Experimental Animals Wistar male rats weighing 250 to 800 grams were used in each group, and 5 rats in each group were gavaged with a solution of 20 mg As / kg body weight of arsenic trioxide (99.9% purity). At 30, 16, and 1, 2, 3, 7, 10, 30, 60 and 120 days after the administration, the four kinds of arsenic metabolites in the organs, tissues, blood, Content, the results are as follows: 1. Blood arsenic trioxide metabolites total blood arsenic concentrations in the blood 6 hours after administration rose sharply, reaching the highest value after two days, 200 times the control group, 120 days after the still