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为了研究青蒿琥酯对恶性疟原虫早期配子体（ＰＦＧｅ）的作用，选择经骨髓涂片查到ＰＦＧｅ，但未有成熟配子体（ＰＦＧｍ）的脑型疟患者３４例，对其治疗前后ＰＦＧｅ的改变进行了专门观察。方法是采用青蒿琥酯静脉给药，５ｄ疗程总量３６０～４２０ｍｇ。治疗后，于当天（Ｄ０）和第７天（Ｄ７）或加第１０天（Ｄ１０）作骨髓涂片，观察ＰＦＧｅ的变化，每天取外周血片计算ＰＦＧｅ和ＰＦＧｍ数，连续２８ｄ或直至ＰＦＧ消失。结果３４例治疗后，Ｄ７骨髓ＰＦＧｅ消失２７例，Ｄ１０消失７例。２９例外周血查到ＰＦＧｅ者，全部于治疗后２～８ｄ消失，平均（４．５±１．９）ｄ。３３例骨髓和外周血均一直未查到ＰＦＧｍ，仅１例于首剂给药后１０ｈ，外周血查到少量ＰＦＧｍ，持续至Ｄ１１消失。结果表明，青蒿琥酯对Ⅰ～Ⅳ期ＰＦＧｅ都有杀灭作用。只有极少数接近成熟的配子体未被控制而出现于外周血液，但持续时间较短
In order to investigate the effect of artesunate on early stage gametophyte (PFGe) of Plasmodium falciparum, 34 patients with cerebral malaria who had PFGe detected by bone marrow smear but no adult gametophyte (PFGm) were selected and their PFGe changes before and after treatment A special observation was conducted. Method is to use artesunate intravenous administration, 5d course of 360 ~ 420mg total. After treatment, bone marrow smears were taken on the day (D0) and on the 7th day (D7) or on the 10th day (D10) to observe the changes of PFGe. Peripheral blood slices were taken daily to calculate the number of PFGe and PFGm for 28 days or until PFG disappeared . Results 34 cases of treatment, D7 bone marrow PFGe disappeared in 27 cases, D10 disappeared in 7 cases. 29 cases of peripheral blood found PFGe, all disappeared 2 ~ 8d after treatment, with an average of (4.5 ± 1.9) d. 33 cases of bone marrow and peripheral blood were not detected PFGm, only 1 case of the first dose after 10h, a small amount of PFGm detected in the peripheral blood, until D11 disappeared. The results showed that artesunate has a killing effect on stage Ⅰ ~ Ⅳ PFGe. Only a very small number of mature gametocytes appear uncontrolled in the peripheral blood, but have a short duration