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目的:研究纳洛酮对白细胞介素-1β(IL-1β)致热大鼠发热反应的影响及机制。方法:经大鼠侧脑室微量注射IL-1β建立发热模型,观察纳洛酮对发热大鼠体温的影响,并测定下丘脑中环磷酸腺苷(cAMP)和腹中膈区精氨酸加压素(AVP)含量。结果:纳洛酮减弱了IL-1β致热效应,同时下丘脑中cAMP和腹中膈区AVP含量也相应减少(P<0.01)。结论:纳洛酮能够抑制大鼠IL-1β性发热,其机制可能是抑制下丘脑中cAMP的合成,并且促进腹中膈区AVP的释放。
Objective: To investigate the effect and mechanism of naloxone on febrile response induced by interleukin-1β (IL-1β) in rats. Methods: The model of fever was established by microinjection of IL-1β into the lateral ventricle of rats to observe the effect of naloxone on the body temperature in rats with fever. The levels of cAMP in hypothalamus and arginine vasopressin (AVP) content. Results: Naloxone attenuated the pyrogenic effect of IL-1β, and the content of cAMP in the hypothalamus and AVP in the abdominal diaphragm area also decreased (P <0.01). CONCLUSION: Naloxone can inhibit IL-1β-induced fever in rats. The mechanism may be that it inhibits the synthesis of cAMP in the hypothalamus and promotes the release of AVP in the abdominal diaphragm.