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目的：探讨血管生成与腋淋巴结阴性乳腺癌（ＡＮＮＢＣ） 临床病理及预后关系，为ＡＮＮＢＣ 寻求一种新的预后因子。方法：选择８０ 例随访资料完整的根治或改良根治术后的ＡＮＮＢＣ 女病人（ 中位随访期８ 年，３５ 例术后实施了辅助治疗，４５ 例未接受辅助治疗） 的石蜡标本，用免疫组化方法染色微血管及检测血管内皮生长因子（ＶＥＧＦ）表达， 单因素和多因素方法分析肿瘤微血管密度（ ＭＶＤ） 和ＶＥＧＦ 的表达对ＡＮＮＢＣ 预后的关系。结果： 全部病例ＭＶＤ 平均值为３５－９９±２０－２７ ，ＶＥＧＦ 阳性率为３６－２５ ％ ， 两者均与一般临床病理因素无关， 高复发转移组或ＶＥＧＦ表达阳性组ＭＶＤ 显著高于无病生存组或ＶＥＧＦ 表达阴性组（ Ｐ＜ ０－０１） ，高ＭＶＤ 组（ＭＶＤ ＞ ３５） 或ＶＥＧＦ 阳性组ＯＳ 和ＤＦＳ 曲线低于低ＭＶＤ 组（ＭＶＤ≤３５） 及ＶＥＧＦ 阴性组，有统计学差异（ Ｐ＜ ０－０５ 或Ｐ＜ ０－０１） ，对术后未加辅助治疗的４５ 例病人分析，其结果也一致。分析术后加辅助治疗的３５ 例患者，只有ＶＥＧＦ 阴阳两组间ＤＦＳ 有差异。结论：ＶＥＧＦ 阳性表达者血管生成活跃，ＭＶＤ 值高，高ＭＶＤ、ＶＥＧＦ 表达阳性的ＡＮＮＢＣ 预后差，术?
Objective: To investigate the relationship between angiogenesis and clinical pathology and prognosis of axillary lymph node-negative breast cancer (ANNBC) and to find a new prognostic factor for ANNBC. METHODS: A total of 80 consecutive ANNBC female patients (eight years after median follow-up, 35 post-operative adjuvant and 45 non-adjuvant) after radical or modified radical follow-up data were selected for the paraffin-embedded specimens. Methods were used to stain microvessels and detect vascular endothelial growth factor (VEGF) expression. Univariate and multivariate methods were used to analyze the relationship between tumor microvessel density (MVD) and VEGF expression on ANNBC prognosis. Results: The average MVD in all cases was 35-99±20-27, and the positive rate of VEGF was 36-25 %. Both had nothing to do with the general clinicopathological factors. The MVD in the high recurrence and metastasis group or VEGF expression positive group was significantly higher than that without disease. Survival or VEGF expression negative group (P<0-01), high MVD group (MVD>35) or VEGF positive group OS and DFS curves were lower than those of low MVD group (MVD≤35) and VEGF negative group, with statistical difference (P<0-05 or P<0-01) Analysis of 45 patients who did not receive adjuvant therapy after surgery showed similar results. In the 35 patients analyzed for postoperative adjuvant therapy, only the DF yin and yang showed differences in DFS between the two groups. Conclusion: The angiogenesis is active in VEGF positive expression, and the MVD is high. The prognosis of ANNBC with high MVD and VEGF expression is poor.