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目的:评价丹红注射液辅助治疗糖尿病足(DF)的临床疗效。方法:66例DF患者随机分为观察组和对照组各33例,对照组予常规治疗,观察组在对照组治疗基础上加用丹红注射液,4周为一疗程。评价疗效,测定氧化应激指标,记录不良反应。结果:观察组治愈率36.36%,总有效率为87.88%,均明显高于对照组(P<0.05)。治疗后,观察组患者MDA、LPO明显下降,GSH、SOD升高,与对照组相比,差异均有统计学意义(P<0.05或0.01)。两组治疗期间均无明显不良反应出现。结论:丹红注射液可于糖尿病足的治疗,推测其作用机制部分与其抗氧化作用有关。
Objective: To evaluate the clinical efficacy of Danhong injection in the treatment of diabetic foot (DF). Methods: Sixty-six patients with DF were randomly divided into observation group (33 cases) and control group (33 cases). The control group was given routine treatment. The observation group was treated with Danhong injection on the basis of the control group. Four weeks was a course of treatment. Evaluation of efficacy, determination of oxidative stress indicators, record adverse reactions. Results: The cure rate of the observation group was 36.36%, the total effective rate was 87.88%, which were significantly higher than the control group (P <0.05). After treatment, MDA and LPO in observation group were significantly decreased, GSH and SOD were increased, the difference was statistically significant (P <0.05 or 0.01) compared with the control group. No significant adverse reactions occurred during treatment in both groups. Conclusion: Danhong injection in the treatment of diabetic foot, suggesting that part of its mechanism of action and its antioxidant effects.