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用不同剂量(100mg,50mg)镁尘注入大鼠肺内,在光镜及扫描电子显微镜下观察了染尘动物肺内的病理改变和立体超微结构的病变特点。结果发现,该粉尘可引起粉尘灶,Ⅰ型肺泡上皮细胞损伤,Ⅱ型细胞的增生,肺泡结构的破坏,肺气肿,呼吸道炎症和肺间质纤维化。100mg剂量组的病理变化比50mg组更为明显。作者认为,镁矿尘不是惰性粉尘,并提出应注意镁矿尘的职业危害以保护工人健康。
The lungs of rats were injected with different doses (100 mg, 50 mg) of magnesium dust, and the pathological changes and pathological changes of the three-dimensional ultrastructure in the lungs of the dust-exposed animals were observed under light microscope and scanning electron microscope. The results showed that the dust can cause dust stove, type I alveolar epithelial cell injury, type II cell proliferation, destruction of alveolar structure, emphysema, respiratory inflammation and interstitial fibrosis. The pathological changes of 100mg dose group were more obvious than those of 50mg dose group. The author believes that magnesium dust is not inert dust, and proposed that the occupational hazards of magnesium dust should be paid attention to protect the health of workers.