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治疗系统性红斑狼疮(SLE)常用的非激素类抗类药物如异丁苯丙酸(ibuprofen)可引起无菌性脑膜炎,本文报告1例 SLE 用该药以及换用甲苯酰吡(?)乙酸(tolmefin)治疗后均发生了无菌性脑膜炎,后者更为严重。停药后均即恢复。21岁女性 SLE,临床有关节炎、肺炎、贫血、血小板减少和高滴度抗核抗体,用小剂量强的松治疗后控制症状2年。于1978年用异丁苯丙酸治疗1周后,发生低热、头痛、畏光、淋巴结肿和结膜炎等。脑脊液压力300mm H_2O,无血细胞,蛋白质正常。周围血白细胞9,800/mm,硷性磷酸酶269(正常<115)U/L(SMACJ),转氨酶值正常。停用异丁苯丙酸后症状迅速恢复,3天后 SGOT 2,000(正常<200)U/L,SGPT1,175(正常<40)U/L;乳酸脱氢酶6,500(正常<200)U/L;硷性磷酸酶340
Treatment of systemic lupus erythematosus (SLE) commonly used non-hormonal anti-inflammatory drugs such as ibuprofen (ibuprofen) can cause aseptic meningitis, the paper reports 1 SLE with the drug and exchange with toluoacid (?) Aseptic meningitis occurred after treatment with tolmefin, the latter being more severe. Resumed after stopping treatment. 21-year-old woman SLE, clinical arthritis, pneumonia, anemia, thrombocytopenia and high titer antinuclear antibody, controlled by low-dose prednisone after 2 years of treatment. In 1978 with ibuprofen treatment for 1 week, low fever, headache, photophobia, swollen lymph nodes and conjunctivitis. Cerebrospinal fluid pressure 300mm H_2O, no blood cells, normal protein. Peripheral blood leukocytes 9,800 / mm, alkaline phosphatase 269 (normal <115) U / L (SMACJ), normal transaminase value. Symptoms recovered rapidly after discontinuation of ibuprofen, with SGOT 2,000 (normal <200) U / L, SGPT1,175 (normal <40) U / L after 3 days; lactate dehydrogenase 6,500 (normal <200) U / L ; Alkaline phosphatase 340