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目的分析吉林省复治涂阳结核病患者的耐药谱资料,为耐药结核病防治工作提供参考依据。方法采用随机抽样的方法,选取吉林省30个监测点630例复治涂阳结核病患者,采用比例法对分离的结核分枝杆菌菌株进行鉴定及药敏试验,分析结核分枝杆菌的获得性耐药情况及影响因素。结果纳入复治涂阳患者630例,培养阳性597例,阳性率为94.8%;获得性耐药率为53.94%;获得性耐多药率为23.12%。结论吉林省结核病患者的耐药率日益趋高,复治患者是主要的耐药人群,应加强耐药结核病监测,有效预防和控制耐药结核病的产生和蔓延。
Objective To analyze the drug resistance spectrum of patients with smear positive smear positive tuberculosis in Jilin Province and provide reference for the prevention and treatment of drug resistant tuberculosis. Methods A random sampling method was used to select 630 cases of retreated smear-positive tuberculosis patients from 30 surveillance sites in Jilin Province. The isolated strains of Mycobacterium tuberculosis were identified and drug susceptibility test by proportional method, and the acquired resistance of Mycobacterium tuberculosis Drug situation and influencing factors. Results There were 630 cases of smear-positive smear positive smears, 597 cases were positive in culture, the positive rate was 94.8%, the acquired drug resistance rate was 53.94%, and the acquired multidrug resistance rate was 23.12%. Conclusions The resistance rate of TB patients in Jilin Province is increasing day by day. Patients in retreatment are the major drug-resistant population. Monitoring of drug-resistant TB should be strengthened to effectively prevent and control the emergence and spread of drug-resistant TB.