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目的探讨妊娠高血压疾病患者应用硫酸镁联合硝苯地平治疗的临床疗效。方法收集商丘市妇幼保健院2010年1月至2014年3月收治的妊娠高血压疾病患者78例,随机分为观察组与对照组各39例,对照组给予静脉滴注硫酸镁治疗,观察组在对照组治疗的基础上联合硝苯地平口服治疗,对两组患者疗效及妊娠结局进行对比。结果两组患者经治疗后观察组总有效率为94.87%,对照组为79.49%,观察组显著优于对照组,差异有统计学意义(P<0.05)。观察组患者中产后出血、胎盘早剥、早产、新生儿呼吸窘迫及新生儿死亡等不良妊娠结局显著低于对照组(P<0.05)。结论硫酸镁联合硝苯地平治疗妊娠高血压疾病疗效显著,还可以改善产妇的妊娠结局,值得临床应用推广。
Objective To investigate the clinical efficacy of magnesium sulfate combined with nifedipine in patients with pregnancy-induced hypertension. Methods 78 cases of pregnancy-induced hypertension patients admitted from January 2010 to March 2014 in Shangqiu MCH were randomly divided into observation group (39 cases) and control group (39 cases). The control group was given intravenous dripping of magnesium sulfate. The observation group In the control group based on the combination of nifedipine oral treatment, the efficacy of the two groups of patients and pregnancy outcomes were compared. Results After treatment, the total effective rate of the observation group was 94.87%, while that of the control group was 79.49%. The observation group was significantly better than the control group, the difference was statistically significant (P <0.05). In the observation group, adverse pregnancy outcomes such as postpartum hemorrhage, placental abruption, premature birth, neonatal respiratory distress and neonatal death were significantly lower than those in the control group (P <0.05). Conclusion Magnesium sulfate combined with nifedipine treatment of hypertensive disorders of pregnancy significant effect, but also can improve maternal pregnancy outcomes, it is worth promoting the clinical application.