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目的：探讨游离ＰＳＡ比值（Ｆ／Ｔ－ＰＳＡ）对Ｔ－ＰＳＡ值在４～１０μｇ·Ｌ１之间，且肛指检查（ＤＲＥ）正常的良性前列腺增生（ＢＰＨ）和前列腺癌（ＰＣ）鉴别诊断的意义。方法：对Ｔ－ＰＳＡ值在４～１０μｇ·Ｌ１之间且ＤＲＥ正常的８例ＰＣ和１０例ＢＰＨ患者的Ｆ／Ｔ－ＰＳＡ进行回顾性分析。血液中的Ｆ－ＰＳＡ和Ｔ－ＰＳＡ值均用放射免疫法测定。结果：ＰＣ组和ＢＰＨ组的Ｔ－ＰＳＡ值分别是６．２１μｇ·Ｌ１和６．１５μｇ·Ｌ１，２组相比无显著性差异（Ｐ＞０．０５），而Ｆ／Ｔ－ＰＳＡ分别是０．１１和０．２１，２组相比有显著性差异（Ｐ＜０．０１），当取Ｆ／Ｔ－ＰＳＡ阈值为＜０．１５时，鉴别诊断的准确性最高，为７７．７８％，敏感性和特异性分别是８７．５０％和７０．００％。结论：Ｆ／Ｔ－ＰＳＡ有助于鉴别Ｔ－ＰＳＡ值在４～１０μｇ·Ｌ１之间且ＤＲＥ正常的ＢＰＨ和ＰＣ，可减少不必要的活检，推荐使用Ｆ／Ｔ－ＰＳＡ阈值为＜０．１５。
Objective: To investigate the effect of free PSA ratio (F / T-PSA) on benign prostatic hyperplasia (BPH) and prostate cancer (PC) with T-PSA values of 4 ~ 10μg · L1 and normal anal finder examination (DRE) Significance of differential diagnosis. Methods: The F / T-PSA of 8 PC patients with normal DRE and 10 BPH patients with T-PSA values between 4 and 10 μg · L-1 were retrospectively analyzed. Blood F-PSA and T-PSA values were measured by radioimmunoassay. Results: The T-PSA values of PC group and BPH group were respectively 6.21μg · L1 and 6.15μg · L12, there was no significant difference (P> 0.05), but F / T -PSA were 0.11 and 0.21, respectively, there was a significant difference between 2 and 2 groups (P <0.01). When the F / T-PSA threshold was <0.15, the accuracy of differential diagnosis was the highest, Was 77.78%, the sensitivity and specificity were 87.50% and 70.00% respectively. Conclusion: F / T-PSA can help to identify BPH and PC with T-PSA value of 4 ~ 10μg · L1 and normal DRE, which can reduce unnecessary biopsy. It is recommended to use F / T-PSA threshold < 0.15.