论文部分内容阅读
犬失血性休克五小时,在电镜下可见心、肺、肝、小肠和肾等重要器官出现明显的结构损伤,具体变化如下:心肌纤维水肿,核周胞浆增多,肌原纤维粗细不均,间距变大,肌丝分散并有溶解;闰盘变直,有不同程度的肌丝解离;肌质网和横小管扩张;线粒体凝集变性,基质局灶性空泡化,外膜破裂,偶见巨大线粒体(图1)。肺泡内含水肿液;肺泡Ⅰ型细胞肿大,线粒体肿胀,肺泡Ⅱ型细胞增多,嗜锇性板层小体减少或变空,肺泡隔内毛细血管内皮细胞肿胀,基膜变薄,腔内有血小板、粒细胞聚集及微血栓形成(图2)。肝细胞索断裂,肝细胞游离在极度扩张的Disse间隙和肝窦内,肝细胞变大变圆,表面微绒毛消失,细胞膜破裂,线粒体高度肿胀,嵴断裂或消失,可见巨大线粒体,内含副结晶,不少肝细胞核浓缩,
Five hours after hemorrhagic shock in dogs, obvious structural damage was found in vital organs such as heart, lung, liver, small intestine and kidney under the electron microscope. The specific changes were as follows: myocardial fiber edema, perinuclear cytoplasm, uneven thickness of myofibrils, Intermittent enlargement, filaments scattered and dissolved; Intercalated disc straightened, there are different degrees of myofilament dissociation; sarcoplasmic reticulum and lateral tubule dilatation; mitochondrial coagulation degeneration, stromal focal vacuolation, rupture of the outer membrane, even See huge mitochondria (Figure 1). Alveolar edema; Alveolar type I cell swelling, mitochondria swelling, increased alveolar type II cells, osmiophilic lamellar bodies reduce or empty, alveolar septa capillary endothelial cells swelling, thinning of the basement membrane, intraluminal There are platelets, granulocyte aggregation and microthrombosis (Figure 2). Liver cell cord rupture, liver cell dissociation in the extremely widened Disse gap and hepatic sinusoid, hepatocyte enlargement and rounding, disappearance of surface microvilli, cell membrane rupture, mitochondria highly swollen, crest rupture or disappearance, showing a huge mitochondria, containing the deputy Crystallization, many liver cell nucleus concentration,