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目的检测并探讨类风湿性关节炎(RA)患者血清中补体(C3、C4)、C-反应蛋白(CRP)及免疫球蛋白水平(IgA、IgG、IgM)水平的变化及其对疾病的影响。方法采用速率散射比浊法检测60例RA患者与40例健康人血清C3、C4、CRP、IgA、IgG、IgM水平,比较30例RA患者治疗前后检测结果。结果RA患者血清中C3、CRP、IgA、IgG和IgM检测水平显著高于健康对照组(P<0.01),补体C4明显高于健康对照组(P<0.05),治疗后CRP检测水平显著低于治疗前(P<0.01),而治疗前后C3、C4、IgA、IgG、IgM无显著变化(P>0.05)。结论补体、CRP、免疫球蛋白均参与类风湿性关节炎的发病,CRP还参与类风湿性关节炎的发展过程,观察补体、CRP和免疫球蛋白水平变化对疾病的诊断、指导治疗和评价预后有重要意义。
Objective To detect and investigate the changes of complement (C3, C4), C-reactive protein (CRP) and immunoglobulin levels (IgA, IgG, IgM) in serum of patients with rheumatoid arthritis . Methods Serum levels of C3, C4, CRP, IgA, IgG and IgM in 60 patients with RA and 40 healthy controls were detected by rate nephelometry. The results of 30 patients with RA were compared before and after treatment. Results The levels of C3, CRP, IgA, IgG and IgM in serum of RA patients were significantly higher than those in healthy controls (P <0.01), complement C4 was significantly higher than that in healthy controls (P <0.05), and the levels of CRP were significantly lower Before treatment (P <0.01), there was no significant change of C3, C4, IgA, IgG and IgM before and after treatment (P> 0.05). Conclusion Complement, CRP and immunoglobulin are all involved in the pathogenesis of rheumatoid arthritis. CRP is also involved in the development of rheumatoid arthritis. To observe the changes of complement, CRP and immunoglobulin levels in the diagnosis, treatment and evaluation of prognosis There’s important meaning.