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为了研究白血病化疗过程中肝功能损害的病因，测定了56例急性白血病化疗前后肝功能，并提出了药物性肝脏损害及白血病细胞肝脏浸润的诊断方法。56例患儿中36例（64．3％）有肝功能受损，其中29例43例次发生药物性肝脏损害，白血病肝浸润9例，2例肝浸润时均无骨髓、中枢等复发证据。4例发生病毒性肝炎。对不同类型肝损害进行治疗，各种肝脏损害恢复时间平均为：药物性8．1天，白血病肝浸润7天，病毒性肝炎30天。结果表明：急淋患儿在诱导及强化治疗过程中易发生药物性肝炎，左旋门冬酰氨酶是引起药物性肝炎最主要药物，其次是6-巯基嘌呤、甲氨喋呤；肝脏可能是急淋白血病的庇护所，环磷酰胺试验治疗对肝脏浸润早期诊断具有重要诊断价值。
In order to study the etiopathogenisis of liver dysfunction during chemotherapy of leukemia, the liver function of 56 patients with acute leukemia before and after chemotherapy was determined and the diagnosis of drug-induced liver damage and liver infiltration of leukemia cells were proposed. Of the 56 children, 36 (64.3%) had impaired liver function, including 29 cases of drug-induced liver damage in 29 cases and 9 cases of leukemia with liver infiltration. There was no evidence of recurrence of bone marrow or center in 2 cases of liver infiltration . 4 cases of viral hepatitis. Treatment of different types of liver damage, a variety of liver damage recovery time average: drug 8.1 days, leukemia liver infiltration 7 days, viral hepatitis 30 days. The results showed that: acute leaning children in the induction and intensive treatment prone to drug-induced hepatitis, L-asparaginase is the most important drug caused by drug-induced hepatitis, followed by 6-mercaptopurine, methotrexate; liver may be Acute leukemia in shelters, cyclophosphamide test treatment of early diagnosis of liver invasion has important diagnostic value.