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近年来肿瘤药物治疗效果多不理想,主要是由于肿瘤细胞发生了多药耐药。即肿瘤细胞接触一种化疗药物并产生耐药性,同时对其他多种结构和作用机制不同的化疗药物亦产生耐药性。目前,这方面的研究已经成为了肿瘤研究领域的热点。已知的多药耐药机制包括P-糖蛋白(P-gp)、多药耐药相
In recent years, the efficacy of oncology drugs is not ideal, mainly due to multidrug resistance of tumor cells. That tumor cells exposed to a chemotherapeutic drug and drug resistance, while a variety of other structures and mechanisms of action of different chemotherapeutic drugs also have resistance. At present, research in this area has become a hot area in cancer research. Known multidrug resistance mechanisms include P-glycoprotein (P-gp), multidrug resistance phase