论文部分内容阅读
目的探讨奥美拉唑、阿莫西林、甲硝唑三联疗法治疗幽门螺杆菌(H.pylori)消化性溃疡的临床疗效。方法选择2010年3月至2011年3月本院收治的70例H.pylori阳性消化性溃疡患者,按照随机对照原则,分为治疗组和对照组,治疗组采用奥美拉唑、阿莫西林和甲硝唑三联治疗,对照组采用雷尼替丁、阿莫西林和甲硝唑三联治疗,比较2组疗效及H.pylori清除率和不良反应发生情况。结果治疗组总有效率为85.7%,对照组总有效率为65.7%,2组比较差异有统计学意义(P<0.05);治疗组H.pylori转阴24例,H.pylori清除率为68.6%,对照组H.pylori转阴10例,H.pylori清除率为28.6%,2组差异有统计学意义(P<0.01);治疗组和对照组不良反应发生率分别为8.6%和5.7%,差异无统计学意义(P>0.05)。结论奥美拉唑、阿莫西林和甲硝唑三联疗法治疗幽门螺杆菌感染消化性渍疡效果明显,值得在临床推广应用。
Objective To investigate the clinical efficacy of omeprazole, amoxicillin and metronidazole in the treatment of peptic ulcer of Helicobacter pylori. Methods 70 patients with H.pylori-positive peptic ulcer admitted to our hospital from March 2010 to March 2011 were randomly divided into treatment group and control group. The treatment group was omeprazole, amoxicillin And metronidazole triple therapy, the control group with ranitidine, amoxicillin and metronidazole triple therapy, the efficacy of two groups and H.pylori clearance and adverse reactions were compared. Results The total effective rate was 85.7% in the treatment group and 65.7% in the control group, with significant difference between the two groups (P <0.05). In the treatment group, 24 cases were negative for H.pylori and the clearance rate of H.pylori was 68.6 %, The control group H.pylori negative in 10 cases, H.pylori clearance rate was 28.6%, the difference between the two groups was statistically significant (P <0.01); the incidence of adverse reactions in the treatment group and the control group were 8.6% and 5.7% , The difference was not statistically significant (P> 0.05). Conclusion Omeprazole, amoxicillin and metronidazole triple therapy for the treatment of H. pylori infection of peptic ulcer effect is obvious, it is worth in the clinical application.