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在大鼠、家兔与人类中,已发现促性腺激素的短反馈机制,但促性腺激素的作用部位是下丘脑还是垂体尚未清楚.本工作观察去势妇女注射hCG后血浆促黄体生成素释放激素(LHRH)的变化以研究促性腺激素短反馈作用的部位.受试者为16名36～48岁妇女,行全子宫与双侧附件切除术已两周以上.其中6人于上午8时给予hCG10,000IU一次肌注;5人于上午8时给hCG40,000IU一次肌注;另5人肌注生理盐水作为对照.在注射前后各于30分钟、1、2、4小时收集血
In rats, rabbits and humans, we have found a short feedback mechanism of gonadotrophin, but the role of gonadotrophin in the hypothalamus or pituitary is not yet clear.The purpose of this study was to observe the release of luteinizing hormone Hormone (LHRH) changes in order to study the role of gonadotropin short feedback site for the subjects of 16 women aged 36 to 48, hysterectomy and bilateral attachment resection has been more than two weeks, of which 6 were at 8:00 am One intramuscular injection of hCG 10,000 IU was given to the hCG 40,000 IU intramuscularly at 8:00 AM and the other 5 were intramuscularly injected with normal saline as controls at 30 minutes, 1, 2 and 4 hours before and after injection