钛铝金属间化合物多孔材料筛选大黄蛰虫方抗动脉血栓形成机理(英文)

• 作 者: 万玲 王战义 魏星 李佶阳 钟广伟 段晓鹏 贺福元 江垚 王东生
• 机 构: 中南大学湘雅医院,河南禹州市中医院,湖南中医药大学,中南大学粉末冶金学院,
• 出 处: Transactions of Nonferrous Metals Society of China
• 发表日期: 2012年12期
• 关键词: 多孔材料 抗血栓形成作用 大黄蛰虫方 蜇虫 动脉血栓形成 大鼠 金属间化合物 孔径 中药分离筛选 英文

探讨经过钛铝金属间化合物多孔材料分离筛选的大黄蛰虫方抗血栓形成机理。将通过钛铝金属间化合物多孔材料分离筛选的大黄蛰虫方干预大鼠,收集血液、血栓。结果表明,钛铝金属间化合物多孔材料能有效分离筛选大黄蛰虫方,以孔径为15μm的效果最优。大黄蜇虫方能升高6-keto-PGF1α,降低TXD2,降低血小板含量,有良好的抗动脉血栓形成作用。多孔材料处理过的药物具有良好的抗血栓形成作用。

To investigate the anti-thrombosis mechanism of rhubarb and stolonosome after the screening and screening of porous materials of titanium-aluminum intermetallic compound. Rhizopus stolonifer, which was isolated and screened by the porous material of titanium-aluminum intermetallic compound, was used to interfere with the rats and blood and thrombus were collected. The results showed that the porous titanium-aluminum intermetallic compound could effectively separate and screen the rhubarb and zoostasis, and the best effect was obtained when the pore size was 15μm. Rhubarb stinger can increase 6-keto-PGF1α, reduce TXD2, reduce platelet content, have a good anti-arterial thrombosis. Porous material-treated drug has a good antithrombotic effect.