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目的：探讨综合实验教学模式在护理学基础实验教学中的应用与效果。方法将2013级本科护理专业学生87名随机分为试验组42和对照组45,试验组采用综合实验教学模式,即将以病例教学法、以问题为导向的教学法、情境教学法等多种教学方法综合应用；对照组采用传统的教学方法。采用临床综合技能评价及问卷调查的方法分析教学效果。结果试验组临床综合技能评价(=3.62,<0.01)显著优于对照组,试验组学生对各项教学效果评价较好。结论运用综合实验教学模式进行护理学基础教学有利于提高学生的临床综合技能及学生对教学效果的满意度。“,”Objective To explore the effects of Comprehensive Experiment teaching model on Medical Nursing teaching in Basic nursing experimental teaching. Methods Ninety vocational nursing students enrolled in 2013 were randomly divided into experimental group (n=42)and control group (n=45). Comprehensive Experiment teaching model was used in the experimental group,the teaching methods included clinical case teaching with simple standardized patients,problem-based learning teaching and situational simulation teaching et al. The conventional teaching methods were conducted in the control group. The teaching effects were evaluated by exams,clinical skills performance evaluation,and a questionnaire survey. Results The average score of clinical skills performance evaluation)(=3.62,<0.01)of experimental group were better than those of control group. And the nursing students in the experimental group gave a high evaluation about the teaching effect with the teaching methods. Conclusion Application of Comprehensive Experiment teaching model in Medical Nursing can improve the exam scores and improve the learning satisfaction .