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p6 3基因是由Osada于 1998年发现的另一个p5 3基因家族成员 ,定位于 3q2 7 3q2 9。p6 3与 p5 3蛋白具有非常相似的结构和功能 ,目前已被认为是一个候选抑癌基因。我们应用原位杂交方法分别检测喉鳞状细胞癌、癌旁增生组织、非典型增生组织和声带息肉中的 p6 3基因表达程度 ,藉
The p6 3 gene is another p5 3 gene family member discovered by Osada in 1998 and is located on 3q2 7 3q2 9. p6 3 has a very similar structure and function to p5 3 protein and is now considered as a candidate tumor suppressor gene. We used in situ hybridization to detect the expression of p6 3 gene in laryngeal squamous cell carcinoma, paracancer tissue, atypical hyperplastic tissue and vocal cord polyp