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左旋溶肉瘤素(Melphalan,MDH)又称左旋苯丙氨酸氮芥。自1978年开始用于治疗小儿肿瘤。但青春期使用MDH后产生原发性卵巢衰竭则尚未见报道。虽然已有成年人间歇性低剂量使用MDH后发生卵巢衰竭的报告。本文报告3例青春期妇女使用MDH后出现原发性卵巢衰竭。 例1:患者为患有非转移性尤因氏肉瘤(Ewi-ng’s sarcoma),源自肋骨。经过局部切除,放射疗法以及使用环磷酰胺、长春新碱、阿霉素、放线菌素D的化学疗法后症状完全缓解。使用放射疗法和鬼臼乙叉甙(etoposide)治疗21个月后复发纵膈肿瘤,随之用MDH两个疗程治疗。在接受MDH之前,患者12岁即有正常初潮,其后月经规律,血清卵泡刺激素(FSH)、黄体激素(LH)、
Melphalan (MDH), also known as melphalan. Since 1978 for the treatment of pediatric tumors. However, adolescent use of MDH after primary ovarian failure have not been reported. Although there are reports of ovarian failure in MDS following intermittent low doses in adults. This article reports three cases of adolescent women with MDH after primary ovarian failure. Example 1: The patient is suffering from non-metastatic Ewi-ng’s sarcoma, derived from the ribs. After partial resection, radiotherapy and chemotherapy with cyclophosphamide, vincristine, doxorubicin, and dactinomycin, symptoms completely resolved. Mediastinal tumors recurred after 21 months of treatment with radiotherapy and etoposide followed by two courses of MDH. Prior to MDH, patients had normal menarche at 12 years of age, followed by regular menstruation, serum follicle stimulating hormone (FSH), luteinizing hormone (LH),