砷、镉联合染毒大鼠肾毒性效应及生物接触限值的探讨

• 作 者: 洪峰 金泰■
• 机 构: 贵阳医学院公共卫生学院,复旦大学公共卫生学院 贵州贵阳550004
• 出 处: 毒理学杂志
• 发表日期: 2005年S1期
• 关键词: 染毒 接触限值 毒性效应 联合毒性 基准剂量 鼠肾 内剂量 大鼠 氯化镉 肾脏毒性

目的探讨砷、镉联合染毒大鼠肾毒性效应、剂量-效应关系以及砷、镉联合肾毒性的生物标志物和生物接触限值。方法以雄性Wistar大鼠为实验动物,根据析因实验设计进行镉、砷联合肾脏毒性实验。用氯化镉(50、150mg/L)和三氧化二砷(25、100mg/L)溶于水中单独或联合染毒3个月。以摄入

Objective To investigate the nephrotoxic effect, dose-response relationship, biomarkers of arsenic and cadmium combined with nephrotoxicity and the limits of biological exposure in rats exposed to arsenic and cadmium. Methods Male Wistar rats were used as experimental animals, and cadmium and arsenic combined with nephrotoxicity were tested according to the experimental design. Dissolved in water with cadmium chloride (50,150 mg / L) and arsenic trioxide (25,100 mg / L) separately or in combination for 3 months. Ingestion