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目的探讨肿瘤坏死因子α（TNF—α）在肝硬变门脉高压症（PHT）发病中的作用。方法本研究采用MTT法测定对照组、肝硬变PHT患者外周血血清TNF—α水平，并观察它与不同程度肝功能损害（Child分级）的关系。结果肝硬变PHT患者血清TNF—α水平显著高于对照组（P＜0．01），其中ChildC级TNF—α水平较ChildB级显著升高（P<0．05），ChildB级又显著高于ChildA级（P＜0．05）。结论TNF—α既参与了肝硬变PHT的形成，同时又是一种肝损因子；检测血清TNF-α水平有助于了解肝功能状态。
Objective To investigate the role of tumor necrosis factor-α (TNF-α) in the pathogenesis of cirrhosis and portal hypertension (PHT). Methods In this study, the levels of serum TNF-α in peripheral blood of patients with PHT and cirrhosis were determined by MTT assay and the relationship between the level of TNF-α and the degree of liver damage (Child classification) was observed. Results The serum levels of TNF-α in PHT patients with cirrhosis were significantly higher than those in the control group (P <0.01). The level of Child-C TNF-α in Child-cirrhosis was significantly higher than that in Child B-grade (P <0.05) At ChildA level (P <0.05). Conclusion TNF-α is not only involved in the formation of cirrhosis PHT, but also a hepatic impairment factor. Detecting serum TNF-α level may help to understand the state of liver function.