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目的探讨药物性骨质疏松的特点及规律,为指导临床医生诊断、治疗及合理用药提供依据。方法系统查阅吉林大学第四医院从2008年1月1日至2011年4月30日期间收治的药物性骨质疏松门诊及住院患者的临床资料,进行回顾性研究。结果本组药物性骨质疏松患者共48例,女性28例,男性20例;年龄15～82岁;激素类药物导致该症居首位(64.58%),其他依次为抗癫痫药物(14.58%,苯妥英钠、苯巴比妥等)、甲状腺激素(8.33%)、含铝的抗酸剂(6.25%)、化疗药物和肝素等(2.08%)。结论临床上众多药物均可引起药物性骨质疏松,但不同药物引起临床病症的发生时间有所差异,临床医生应注意鉴别。对于确诊病例,应同时采取多种治疗方法,给予钙剂、维生素D、蛋白质同化激素(苯丙酸诺龙)、维生素C等,有助于避免或推迟本症的发生。
Objective To explore the characteristics and rules of drug-induced osteoporosis and provide the basis for clinicians to diagnose, treat and rationally use drugs. Methods The clinical data of outpatients and inpatients with drug-induced osteoporosis admitted to the Fourth Hospital of Jilin University from January 1, 2008 to April 30, 2011 were retrospectively studied. Results A total of 48 patients with osteoporosis were enrolled in this study. Among them, 28 were female and 20 were male. The age ranged from 15 to 82 years old. Hormone drugs led to the first place (64.58%), followed by antiepileptic drugs (14.58% , Phenytoin, phenobarbital, etc.), thyroid hormones (8.33%), aluminum-containing antacids (6.25%), chemotherapeutics and heparin (2.08%). Conclusion Many clinical drugs can cause drug-induced osteoporosis, but different drugs cause the occurrence of clinical symptoms vary, clinicians should pay attention to identify. For confirmed cases, should take a variety of treatment methods, given calcium, vitamin D, protein anabolic hormone (nandrolone phenylpropionate), vitamin C, etc., help to avoid or delay the onset of the disease.