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目的:研究芪茸保元汤对慢性肾功能不全小鼠模型的治疗作用。方法:采用腺嘌呤小鼠灌胃造成动物模型,实验分为正常对照组、模型组、芪茸保元汤小剂量组(13.9 g 生药/kg)和大剂量组(27.8 g 生药/kg),灌胃1个月,测定小鼠体重、肾重量、血清肌酐(Cr)和尿素氮(BUN)。结果:芪茸保元汤各剂量组能显著降低血清 Cr 和 BUN 水平(P<0.05),大剂量组显著增加动物体重(P<0.05)。结论:芪茸保元汤具有改善模型动物的肾功能的作用。
Objective: To study the therapeutic effect of Qirong Baoyuan Decoction on chronic renal insufficiency mouse model. METHODS: Adenine mice were intragastrically administered to induce animal models. The experiments were divided into normal control group, model group, Qirong Baoyuan Decoction low-dose group (13.9 g crude drug/kg) and large-dose group (27.8 g crude drug/kg). One hour after intragastric administration, body weight, kidney weight, serum creatinine (Cr) and urea nitrogen (BUN) were measured. Results: Qirong Baoyuan Decoction can significantly reduce the serum levels of Cr and BUN in each dose group (P<0.05). The high-dose group significantly increased the body weight (P<0.05). Conclusion: Qirong Baoyuan Decoction can improve the renal function of model animals.