,Isoniazid metabolism and hepatotoxicity

来源 :Acta Pharmaceutica Sinica B | 被引量 : 0次 | 上传用户：toerrisme

【摘要】

：

Isoniazid(INH) is highly effective for the management of tuberculosis.However,it can cause liver injury and even liver failure.INH metabolism has been thought t

【作者】

：

Pengcheng Wang Komal Pradhan Xiao-bo Zhong Xiaochao Ma

【机构】

：

Center for Pharmacogenetics,Department of Pharmaceutical Sciences,School of Pharmacy,University of P

【出处】

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Acta Pharmaceutica Sinica B

【发表日期】

：

2016年05期

【关键词】

：

Isoniazid Metabolism Hepatotoxicity Anti-tuberculosis N-Acetyltransferase 2 Amid

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Isoniazid(INH) is highly effective for the management of tuberculosis.However,it can cause liver injury and even liver failure.INH metabolism has been thought to be associated with INH-induced liver injury.This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury. Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarizes the metabolic pathways of INH and discussed their associations with INH-induced liver injury.

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,Isoniazid metabolism and hepatotoxicity

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