论文部分内容阅读
SpA是一种存在于金黄色葡萄球菌细胞壁中的特异性表面抗原。SpA具有能与人及多种哺乳动物的IgGF C段结合的特性。很多体外试验证明SpA对人和动物的淋巴细胞具有很强的促有丝分裂作用。我们知道淋巴细胞在体外受非特异性促有丝分裂因子刺激后,能转化为淋巴母细胞。淋巴细胞转化率的高低大致与淋巴细胞免疫状态平行。在一定程度上可以反映机体的免疫功能。本试验采用不同剂量的SpA与SpA菌腹腔(IP)、皮下(SC)和静脉(IV)三种途径免疫615近交系小鼠,观察对小鼠外周血淋巴细胞转化的效果,获得了有意义的结果。
SpA is a specific surface antigen present in the cell wall of Staphylococcus aureus. SpA has the property of binding to human and various mammalian IgGF C segments. Many in vitro experiments have demonstrated that SpA has a strong mitogenic effect on human and animal lymphocytes. We know that lymphocytes can be transformed into lymphoblasts after being stimulated by nonspecific mitogenic factors in vitro. The lymphocyte transformation rate is roughly parallel to the lymphocyte immune status. To a certain extent, it can reflect the body’s immune function. In this experiment, 615 inbred mice were immunized with different doses of SpA and SpA peritoneal (IP), subcutaneous (SC) and intravenous (IV) pathways to observe the effect on peripheral blood lymphocyte transformation in mice. Meaningful result.