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目的:探讨大豆异黄酮(SIF)对AD大鼠海马Apo-E4的影响。方法:采用Aβ双侧海马注射建立阿尔茨海默病(AD)大鼠模型,分组后给予不同剂量大豆异黄酮,Morris水迷宫实验观察大鼠学习记忆能力的变化,HE染色观察大鼠海马组织形态结构变化,ELISA法测定海马组织Apo-E4含量。结果:大豆异黄酮可改善AD大鼠的学习记忆能力(P<0.01),减少海马神经元丢失,显著性降低Apo-E4含量(P<0.01)。结论:大豆异黄酮可能通过降低AD大鼠海马Apo-E4的含量改善AD大鼠学习记忆能力。
Objective: To investigate the effect of soybean isoflavone (SIF) on Apo-E4 in hippocampus of AD rats. Methods: Alzheimer’s disease (AD) rat models were established by injection of Aβ bilateral hippocampus. The rats were divided into groups and given different doses of soy isoflavones. Morris water maze test was used to observe the learning and memory abilities of rats. HE staining was used to observe the changes of hippocampus Morphological and structural changes, ELISA assay Apo-E4 content in the hippocampus. Results: Soy isoflavones can improve the learning and memory ability of AD rats (P <0.01), reduce the loss of hippocampal neurons, and significantly reduce the content of Apo-E4 (P <0.01). Conclusion: Soy isoflavones may improve the learning and memory abilities of AD rats by decreasing the content of Apo-E4 in hippocampus of AD rats.