Re-expression of RASSF1A by 5-Aza-CdR Induced Demethylation of the Promoter Region in Human Biliary

• 作 者: 左石 陈勇军 徐立宁 唐启彬 邹声泉
• 机 构: DepartmentofGeneralSurgeryTongjiHospitalTongjiMedicalCollegeHuazhongScience&,TechnologyUniversity
• 出 处: Journal of Huazhong University of Science and Technology(Med
• 发表日期: 2007年3期
• 关键词: 5-aza-2’-deoxycytidine RASS1A GENE biliary tract carcinoma DNA methylation GENE

Hypermethylation of the promoter region is an important mean for the transcriptional repression of a number of cancer-associated genes, and over-expression and/or increased activity of DNA methyltransferase are considered to be the main cause of promoter