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在寻找有效的抗鼠疫的免疫原时,我们曾用鼠疫菌的某些抗原掺入到化学菌苗内。其中有意义的叫作小鼠毒素,最初是由 Spi-vack 和 Karler 以及 Ajl 等人精制出来的。一方面,所有的研究者都否定该抗原在疾病的发病机制中的重要作用;另一方面也有关于用该制剂建立活性免疫可能性的报道)诚然,报道数量不多)。但是多数作者否认毒素本身有保护作用,而将有增强单相免疫原(活菌苗、F_1等)的保护性能力,看作只起非特异性的佐剂作用。小鼠毒素的分离、提纯方法以及它的物
In the search for effective anti-plague immunogens, we have incorporated some of the Yersinia pestis antigens into chemical vaccines. One of the more interesting mice toxins, originally made by Spi-vack and Karler and Ajl et al. On the one hand, all researchers deny the important role of the antigen in the pathogenesis of the disease; on the other hand, there are reports of the possibility of establishing an active immunity with the preparation. However, most authors deny that the toxin itself has a protective effect and will have the protective ability to enhance the single-phase immunogen (live vaccine, F_1, etc.) as a nonspecific adjuvant. Isolation and purification of mouse toxins and their products