论文部分内容阅读
目的 :研究托吡酯单用或添加治疗癫痫病人的疗效、副作用。方法 :1 43例入组病人填写 4wk发作的逐日志 ,完成后分为 2组 (Ⅰ组 1 0 1例为随访的癫痫病人 ,Ⅱ组 42例为新诊断的癫痫病人 ) ,Ⅰ组病人除原用的抗癫痫药物外加用托吡酯 ,按每周 2 5mg递增 ,无效则加至 2 0 0mg·d-1,分 2次服 ,4wk后原用抗癫痫药开始减量 ,至停用。Ⅱ组单用托吡酯 ,剂量同Ⅰ组。定期随访 ,以用药mo 6时发作减少 5 0 %以上为有效 ,观察疗效及副作用。结果 :Ⅰ组随访病人 1 0 1例 ,其中 80例完成试验 ,有效5 7例 ;Ⅱ组新诊断癫痫病人 42例 ,其中 3 2例完成全部试验 ,有效 2 9例。全组病人中有 41例出现不同程度的副作用。结论 :托吡酯对癫痫病人的发作有良好的疗效 ,副作用轻微 ,多数不需处理。
Objective: To study the efficacy and side effects of topiramate alone or in the treatment of epilepsy. Methods: One hundred and forty-three patients were enrolled in the daily log of 4wk attack. After completion, they were divided into 2 groups (group I: 110 epilepsy patients followed up and group Ⅱ 42 patients newly diagnosed epilepsy). Patients in group I The original anti-epileptic drugs plus topiramate, according to weekly 25mg increments, invalid added to 200mg · d-1, 2 times service, 4wk original anti-epileptic drugs began to reduce, to disable. Group Ⅱ only topiramate, the same dose group Ⅰ. Regular follow-up, mo 6 to reduce the onset of attack more than 50% effective, observe the efficacy and side effects. Results: A total of 101 patients were followed up in group Ⅰ, of which 80 were completed and 57 were effective. In group Ⅱ, 42 newly diagnosed epilepsy patients were included, of which 32 were completed and 29 were effective. There were 41 patients in the entire group with varying degrees of side effects. Conclusion: Topiramate has a good curative effect on epileptic patients with minor side effects, most of which need not be treated.