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肥大细胞的细胞生物学快速深入的研究证实,肥大细胞脱颗粒可由一系列物理、化学刺激经由不同途径诱发,而肥大细胞的功能不仅限于变态反应和前炎症反应,且与正常的生理、病理过程密切相关。近年来发现,肥大细胞在肠易激综合征的发病中发挥关键作用:包括炎症和粘膜的免疫生理、产生大量多功能生物化学介质、与神经免疫联系和脑-肠轴的关系及在肠道高敏感性中都起到重要作用。为此,有必要对肥大细胞的生物学作用进行更深入的研究及重新认识。
Mast cell rapid and in-depth study of cell biology confirmed that degranulation of mast cells by a series of physical and chemical stimuli induced by different ways, while the function of mast cells is not limited to the allergic and anterior inflammatory reactions, and the normal physiological and pathological processes closely related. In recent years, it has been found that mast cells play a key role in the pathogenesis of irritable bowel syndrome, including inflammatory and mucosal immunopathology, production of a large number of multifunctional biochemical mediators, neuroimmunity and brain-gut axis, High sensitivity plays an important role. For this reason, it is necessary to conduct a more in-depth study and re-understanding of the biological role of mast cells.