An efficient and mild protocol for the synthesis of unsymmetrical ureas in the absence of catalyst a

• 作 者: Rahman Hosseinzadeh Yaghoub Sa
• 机 构: Department of Organic Chemistry
• 出 处: 中国化学快报（英文版）
• 发表日期: 2004年期
• 关键词: Unsymmetrical ureas Phenylurea Amines Uncatalyzed reaction

A new practical method for the synthesis of unsymmetrical ureas was achieved by reaction of phenylurea with primary and secondary amines under neutral and mild condition in very good yields. The reaction took place in refluxing dioxane and does not require any catalyst or additives.