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目的探讨纳洛酮在新生儿缺氧缺血性脑病治疗中的临床疗效。方法对我院收治的72例HIE患儿进行治疗分析。结果治疗组总有效率明显优于对照组(P<0.05);治疗组在临床症状消失、原始反射恢复方面明显优于对照组(P<0.05);在治疗3d、7d、10d行新生儿NBNA评分中,治疗组明显高于对照组(P<0.05)。结论纳洛酮可有效促进HIE患儿脑功能恢复,减轻脑水肿及脑细胞坏死的发生,治疗HIE的有效药物,值得推广。
Objective To investigate the clinical efficacy of naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods 72 cases of HIE admitted to our hospital for treatment analysis. Results The total effective rate of the treatment group was significantly better than that of the control group (P <0.05). The clinical symptoms of the treatment group disappeared and the original reflex recovery was significantly better than that of the control group (P <0.05). At 3, 7 and 10 days, The scores in the treatment group were significantly higher than those in the control group (P <0.05). Conclusion Naloxone can effectively promote the recovery of brain function in children with HIE and reduce the occurrence of cerebral edema and necrosis of brain cells. It is worth to be popularized to treat HIE.