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小檗胺能抑制离体豚鼠心房肌的收缩力,自律性和延长功能性不应期,对兴奋性无影响。小檗胺的负性肌力作用随时间延长而加强。小檗胺明显提高肾上腺素对心房肌自律性的阈浓度,此外,小檗胺还能明显延长豚鼠心房肌功能性不应期,这可能是小檗胺抗心律失常作用的原理之一。本实验和其他实验研究均证明,小壁胺和戊脉安两药在较低浓度时使CaCl_2量-效曲线平行右移,而在较高浓度时
Berbamine can inhibit contractility, self-discipline and prolonged functional refractory period of isolated atrial guinea pig atrialkinesis, and has no effect on excitability. The negative inotropic effect of berbamine intensified over time. Berbamine significantly increased the threshold concentration of epinephrine on atrial muscle self-regulation. In addition, berbamine significantly prolonged functional refractory period of atrial myofascial in guinea pigs, which may be one of the mechanisms of anti-arrhythmic effect of berbamine. This experiment and other experimental studies have shown that small wall amine and verapamil two drugs at lower concentrations so that the amount of CaCl2 - effect curve parallel shift to the right, and at higher concentrations