论文部分内容阅读
本文利用层层自组装技术制备了一种新型的Nafion/GNPs/RTIL/MWNTs/GC电极。利用循环伏安法研究对乙酰氨基酚(ACOP)在该修饰电极上的电化学特性。结果表明:ACOP在裸GC电极上表现为不可逆的电极过程,而在Nafion/GNPs/RTIL/MWNTs/GC电极上表现为很好的可逆性,氧化峰电位由0.562 V移至0.413 V,具有0.149 V的电位降;其还原峰电位为0.384 V,峰电位差仅为29 mV。该修饰电极与MWNTs/GC电极和裸GC电极比,具有更高的电催化活性;同时可加速电极与ACOP间的电子转移。本文探索了不同实验条件对该电极性能的影响,在优化的实验条件下,检测ACOP药物的线性浓度范围为2×10 7～4.0×10 4 mol.L 1,线性相关系数为r=0.999 2,其检出限为2.6×10 8 mol.L 1(信噪比为3∶1);回收率为97.9%～100.8%。将该电极用于对乙酰氨基酚片剂中ACOP的含量测定,并与药典方法比较无显著性差异。
In this paper, a new type of Nafion / GNPs / RTIL / MWNTs / GC electrode was prepared by using the layer self-assembly technique. Cyclic voltammetry was used to study the electrochemical properties of acetaminophen (ACOP) on the modified electrode. The results showed that ACOP exhibited irreversible electrode process on bare GC electrode and good reversibility on Nafion / GNPs / RTIL / MWNTs / GC electrode. The oxidation peak potential shifted from 0.562 V to 0.413 V with 0.149 V potential drop; the reduction peak potential of 0.384 V, the peak potential difference of only 29 mV. The modified electrode has higher electrocatalytic activity than the MWNTs / GC electrode and the bare GC electrode, and at the same time accelerates the electron transfer between the electrode and the ACOP. In this paper, we explored the influence of different experimental conditions on the performance of this electrode. Under the optimal experimental conditions, the linear range of ACOP was 2 × 10 7 ~ 4.0 × 10 4 mol·L -1, and the linear correlation coefficient was 0.999 2 , The detection limit was 2.6 × 10 8 mol.L 1 (signal to noise ratio of 3: 1). The recoveries ranged from 97.9% to 100.8%. The electrode was used for the determination of ACOP in paracetamol tablets, and no significant difference compared with the pharmacopoeia.