复方甘草酸苷注射液相关视乳头水肿

• 作 者: 郭冬杰 李静山
• 机 构: 中日友好医院药学部,中日友好医院药学部 北京100029,北京100029
• 出 处: 药物不良反应杂志
• 发表日期: 2007年06期
• 关键词: 复方甘草酸苷注射液 视乳头水肿

32岁男性患者,因慢性乙型肝炎静脉给予复方甘草酸苷注射液40ml加入0.9%氯化钠注射液100ml,1次/d,静脉滴注,共11d,后增加剂量至复方甘草酸苷注射液100ml加入0.9%氯化钠注射液250ml,1次/d,共7d。患者每天在输液过程中均出现头晕、眼胀、轻度视物模糊。停药后视物模糊仍再加重。眼科检查:双眼视乳头水肿,隆起1D,视盘边界不清,有轻微出血。BP90/70mmHg。给予患者维生素B1等药物治疗,数日后患者视乳头水肿有所消退,但视物模糊未改善。

32-year-old male patient, due to chronic hepatitis B intravenous compound glycyrrhizin injection 40ml 0.9% sodium chloride injection 100ml, 1 / d, a total of 11d, after a dose increase to compound glycyrrhizin injection Liquid 100ml 0.9% sodium chloride injection 250ml, 1 time / d, a total of 7d. Patients in the infusion process every day are dizziness, eye swelling, mild blurred vision. After stopping the blurred vision is still aggravating. Eye examination: Binocular papilledema, uplift 1D, optic disc boundary is unclear, there is a slight bleeding. BP90 / 70mmHg. Given to patients with vitamin B1 and other drug treatment, a few days later, patients with optic disc edema receded, but blurred vision has not improved.