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目的：研究抗精神病药对精神分裂症患者细胞因子的影响。方法：符合ICD-10精神分裂症诊断的60名患者，随机分为利培酮组（给予利培酮治疗）和齐拉西酮组（给于齐拉西酮治疗），并以健康对照组比较，对患者在治疗前及治疗8周后测量血浆IL-2、 IL-6及 TNF-α水平，并对患者进行PANSS量表评定。结果：两组患者治疗前后血浆IL-2、IL-6及 TNF-α水平与对照组比较，差异有统计学意义（P＜0.05）。两组患者治疗后血浆IL-2、 IL-6及 TNF-α水平较治疗前降低，差异有统计学意义（P＜0.05）。治疗前IL-2水平与PANSS量表阳性症状评分呈正相关（r=0.54, P＜0.05）治疗后TNF-α与阴性症状分呈显著正相关（r=0.41，P＜0.05）。结论：精神分裂症患者存在免疫功能异常，利培酮和齐拉西酮可以降低精神分裂症患者细胞因子水平。细胞因子水平与精神病理存在一定相关性。“,”Objective:Study of antipsychotics on the cytokines of patients with schizophrenia. Methods:Accord with ICD - 10 schizophrenia diagnosis of 60 patients, randomly divided into risperidone group (given risperidone therapy) and ziprasidone group (give ziprasidone treatment), and comparing with healthy controls, the patients before treatment and 8 weeks after treatment to measure the plasma IL-2, IL 6 and TNF-a level, and PANSS score for the patient. Results:Two groups of patients before and after treatment plasma IL-2, IL 6 and TNF – a level compared with control group, the difference was statistical y significant (P<0.05). Two groups of patients after treatment serum IL 2, IL 6 and TNF –a level was reduced, the difference was statistical y significant (P<0.05). IL-2 level before treatment was positively related with PANSS scale positive symptom score (r=0.54, P<0.05) after treatment TNF- 2 and negative symptoms were significantly positive correlation (r=0.41, P<0.05). Conclusions:Patients with schizophrenia exist immune dysfunction, risperidone and ziprasidone can lower levels of cytokines in patients with schizophrenia. Have a certain correlation between cytokine levels and psychopathology.