论文部分内容阅读
为探讨氯氮平（ＣＺＰ）治疗所致静坐不能的发生率及其相关因素，对２１６例单独服用ＣＺＰ治疗的精神分裂症患者采用修改的Ｓｉｍｐｓｏｎ锥体外系副反应量表评定静坐不能，进行为期８周的前瞻性研究。结果显示，ＣＺＰ治疗所致的静坐不能发生率为１２．９６％，多数发生于治疗的１～３周，使用心得安治疗效果良好；静坐不能的发生与ＣＺＰ治疗剂量和入院时ＢＰＲＳ总分有关，而与性别、年龄、病程等因素无关。作者认为，ＣＺＰ治疗能够引起静坐不能，发生率可能低于氯丙嗪等经典抗精神病药物，其危险因素有待进一步的研究揭示。
In order to investigate the incidence of CTS and its related factors, 216 patients with schizophrenia who were treated with CZP alone were assessed for their sedation by using the modified Simpson extrapyramidal side-reaction scale 8 weeks prospective study. The results showed that CZP treatment of seizures can not occur rate was 12.96%, most occurred in the treatment of 1 to 3 weeks, the use of propranolol treatment effect is good; incidence of seizures and CZP treatment dose and admission BPRS total score , But not with sex, age, duration and other factors. The authors believe that CZP treatment can cause seizures, the incidence may be lower than the classic antipsychotic drugs such as chlorpromazine, the risk factors to be further revealed.