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目的:探讨腮腺原发性鳞状细胞癌的临床特征、病理诊断及鉴别诊断。方法:采用常规HE染色及免疫组化方法分析1例腮腺原发性鳞状细胞癌,并复习相关文献。结果:该病例有明显的形态学特征,肿瘤细胞排列成片状或巢团状,有较多坏死,内见角化珠形成,可见细胞间桥及钙化,部分区域黏液样变,肿瘤细胞侵及部分包膜,细胞大小不一,核染色深,有一定异型性,可见核分裂像。免疫组化结果显示肿瘤细胞ck5/6弥漫阳性(+),p63、Calponin、SMA、S-100及p53不同程度阳性(+),ki-67阳性率约30%。特殊染色:AB阴性;PAS灶性红色。结论:腮腺原发性鳞状细胞癌是一种少见的恶性肿瘤,其临床表现无特异性,易误诊,确诊需依赖病理学检查及免疫组化、特殊染色等。
Objective: To investigate the clinical features, pathological diagnosis and differential diagnosis of parotid primary squamous cell carcinoma. Methods: One case of parotid primary squamous cell carcinoma was analyzed by conventional HE staining and immunohistochemistry. The related literatures were reviewed. Results: There were obvious morphological features in this case. The tumor cells were arranged in the form of flakes or nest, with more necrosis. The keratinized beads formed. The intercellular bridges and calcifications, mucoid changes in some regions, tumor cell invasion And part of the envelope, cell size, nuclear staining dark, there is a certain atypia, mitotic image. The results of immunohistochemistry showed that the expression of ck5 / 6 in tumor cells was positive (+). The positive rate of p63, Calponin, SMA, S-100 and p53 were positive. Special staining: AB negative; PAS focal red. Conclusion: Parotid primary squamous cell carcinoma is a rare malignant tumor. Its clinical manifestations are nonspecific and easily misdiagnosed. The diagnosis depends on pathological examination, immunohistochemistry and special staining.