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多模互补成像可以提高医学诊断精度.多模探针是联合各个成像模式的桥梁,这意味着发展多模式、多功能的纳米探针是非常必要的.本文发展了一种具有靶向性的四氧化三铁核/金壳纳米粒子(Fe3O4@Au)作为核磁和光声双模成像的探针,实验证明Fe3O4@Au纳米粒子具有超顺磁性,可以增强T2序列的核磁信号.此外,该探针同时具有光学吸收性质,可以增强光声信号.在其表面修饰Integrin?v?3单克隆抗体后,该探针对U87-MG肿瘤细胞具有选择靶向性.基于Fe3O4@Au纳米粒子的核磁/光声双模成像将在肿瘤诊断中发挥重大作用.
Multimode complementary imaging can improve the diagnostic accuracy of medical diagnosis.Multi-mode probe is a bridge linking various imaging modes, which means that it is necessary to develop multi-mode and multi-functional nano-probes.This paper develops a targeted Ferroferric oxide / gold nanoparticle (Fe3O4 @ Au) as a probe for both nuclear magnetic and photoacoustic dual-mode imaging proved that the Fe3O4 @ Au nanoparticle has superparamagnetism and can enhance the NMR signal of the T2 sequence.In addition, The probe also has optical absorption properties and can enhance the photoacoustic signal.It has selective targeting to U87-MG tumor cells after the surface modification of Integrin? V? 3 monoclonal antibody.According to the nuclear magnetic properties of Fe3O4 @ Au nanoparticles / Photoacoustic dual-mode imaging will play a major role in tumor diagnosis.