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目的探讨长春瑞滨(NVB)联合顺铂(DDP)的NP方案化疗加热疗治疗中晚期食管癌的临床疗效和毒副反应。方法 41例均为经胃镜、影像学及病理组织学确诊为食管癌的患者,Ⅲ期16例,Ⅳ期25例;鳞癌35例,腺癌6例;病灶位于上段7例,中段24例,下段10例。用国产NVB(盖诺)25mg/m2静脉滴注,每疗程的第1天和第8天各用药1次;DDP80mg/m2,每疗程的第1天静脉滴注1次。每疗程每次用化疗药后2h内深部热疗1次,然后隔2天再做1次,每次60min,每疗程热疗4次。以上治疗21～28d为1个疗程,4个疗程后评价疗效。结果 41例中晚期食管癌患者的有效率为56.1%。主要毒副反应是恶心呕吐和骨髓抑制。结论 NP方案化疗加热疗治疗中晚期食管癌有较好疗效,且毒副反应可以耐受,值得临床推广应用。
Objective To investigate the clinical efficacy and side effects of NP regimen combined with thermotherapy of vinblastine (NVB) and cisplatin (DDP) in the treatment of advanced esophageal cancer. Methods Totally 41 patients were diagnosed as esophageal cancer by gastroscope, radiology and histopathology. There were 16 cases in stage Ⅲ and 25 cases in stage Ⅳ, 35 cases of squamous cell carcinoma and 6 cases of adenocarcinoma. The lesions were located in the upper 7 cases and the middle 24 cases , The next 10 cases. With domestic NVB (Greno) 25mg / m2 intravenous infusion, the first day of each course and the first 8 days of medication 1; DDP80mg / m2, intravenous infusion on the first day of each treatment 1. Each treatment with chemotherapy drugs within 2h after deep hyperthermia 1, and then every 2 days to do 1, each 60min, 4 times per course of hyperthermia. The above treatment 21 ~ 28d for a course of treatment, after 4 courses evaluate the curative effect. Results The effective rate of 41 patients with advanced esophageal cancer was 56.1%. The main side effects are nausea and vomiting and myelosuppression. Conclusion NP regimen hyperthermia treatment of advanced esophageal cancer has a good effect, and toxicity can be tolerated, worthy of clinical application.