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[目的]通过研究痛风患者颈动脉内膜-中膜厚度(IMT)与血尿酸(UA)、C反应蛋白(CRP)的关系,研究UA、CRP在痛风患者动脉粥样硬化的作用。[方法]60例痛风患者,正常对照组40例,分析2组人群空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、血尿酸、C反应蛋白,测定颈动脉内膜-中膜厚度,同时计算体重指数(BMI)。[结果]痛风患者组与正常组比较:年龄、FPG、TG、HDL-C、BMI无统计学差异(均P﹥0.05),UA、CRP、IMT有统计学差异(P﹤0.01或P﹤0.05)。痛风患者IMT与年龄、TC、TG、LDL-c、UA、BMI、CRP呈正相关(P﹤0.05或P﹤0.01)。[结论]UA、CRP水平升高与痛风患者动脉粥样硬化(AS)关系密切,关注痛风患者UA、CRP水平的升高对临床具有重要意义。
[Objective] To investigate the effect of UA and CRP on atherosclerosis in gout patients by studying the relationship between carotid intima - media thickness (IMT) and uric acid (UA) and C - reactive protein (CRP) in gout patients. [Methods] Forty-six patients with gout and 40 normal controls were enrolled in this study. Fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C) LDL-C, serum uric acid and C-reactive protein were detected. The intima-media thickness of the carotid artery was measured and body mass index (BMI) was calculated. [Results] There was no significant difference in age, FPG, TG, HDL-C and BMI between the patients with gout and those in the normal group (all P> 0.05), UA, CRP and IMT ). IMT was positively correlated with age, TC, TG, LDL-c, UA, BMI and CRP in patients with gout (P <0.05 or P <0.01). [Conclusion] The elevated levels of UA and CRP are closely related to the risk of atherosclerosis (AS) in gout patients. It is of clinical importance to pay attention to the increase of UA and CRP levels in patients with gout.