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目的和方法：观察钩体外膜疏水蛋白ＯｍｐＬ３９的免疫保护作用和对豚鼠中枢ｃ－ｆｏｓ基因表达的影响，分别用ＯｍｐＬ３９与钩体死菌苗（ＷＬＣＶ）、生理盐水（ＮＳ）对照免疫豚鼠，用强毒０１７株钩体活菌攻击，处死动物后用新鲜延髓切片观察对比。结果：ＯｍｐＬ３９在豚鼠体内能产生高效价的阳性抗体，免疫保护率为１００％。ＯｍｐＬ３９免疫组豚鼠中枢ｃ－ｆｏｓ基因表达面积比为０．００８６％±０．０００３％，颗粒计数为４６３．０±１．３４个，较ＷＬＣＶ和ＮＳ组显著减少（Ｐ＜０．０５）。结论：ＯｍｐＬ３９有较强的免疫保护作用，对豚鼠中枢ｃ－ｆｏｓ基因的表达有抑制作用。
OBJECTIVE: To observe the immunoprotection of OMPL39 and the expression of c-fos gene in guinea pig central nervous system. The guinea pigs were immunized with OmpL39 and WLCV, NS, Toxoplasma gondii 017 strains of bacteria attack, after the animals were sacrificed with fresh bulbar sections observed contrast. Results: OmpL39 can produce high titer of positive antibodies in guinea pigs with 100% immunoprotection. The expression of c-fos gene in OmpL39 immunized group was 0.0086% ± 0.0003% and the particle count was 463.0 ± 1.34, which was significantly lower than that in WLCV and NS groups (P <0.05). Conclusion: OmpL39 has a strong protective effect on the c-fos gene in guinea pigs.