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目的通过对自然流产夫妇的染色体核型分析,了解异常染色体在自然流产夫妇中的发生机率及关系。方法采用外周血淋巴细胞培养及G显带进行染色体核型分析。结果603对有自然流产史的夫妇中共检出异常染色体核型67例,异常率为5.56%(67/1206),其中:易位12例、倒位15例、多态性变异36例。其它4例。结论染色体异常是导致自然流产的重要原因之一,对于临床反复性的自然流产夫妇应及早进行细胞遗传学检查,以避免盲目治疗。
Objective To investigate the incidence of abnormal chromosomes in spontaneous abortion couples and their relations by analyzing the karyotypes of spontaneous abortion couples. Methods Chromosomal karyotyping was performed using peripheral blood lymphocyte culture and G banding. Results Sixty-three cases of aberrant karyotypes were detected in 603 pairs of couples with spontaneous abortion history. The abnormality rate was 5.56% (67/1206). Among them, 12 cases were translocation, 15 cases were inverted and 36 cases were polymorphic. The other 4 cases. Conclusion Chromosomal abnormalities are one of the most important causes of spontaneous abortion. Couples with spontaneous abortion should undergo early cytogenetic examination to avoid blind treatment.