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氟醛诺酮类药物对由革兰氏阴性菌引起伪感染是最有效的疗法。但是在体外它们对金黄色萄葡球菌和链球菌的活性比对需氧革兰氏阴性杆菌（AGN）的活性低，且在治疗革兰氏阳性菌感染中所起的作用仍不明确，且有争论。过去有争论的主要是链球菌感染，最近也涉及到耐甲氧西林的金黄色
Fluconnolones are the most potent therapeutics for causing pseudovirions by Gram-negative bacteria. But in vitro they are less active against Staphylococcus aureus and Streptococcus than against aerobic Gram-negative bacilli (AGN) and their role in treating Gram-positive infections remains unclear and Controversial. The main controversy in the past has been streptococcal infections, and recently methicillin-resistant golden yellow