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鹅去氧胆酸与熊去氧胆酸均降低胆汁中胆固醇的饱和指数,使胆固醇结石溶解,因熊去氧胆酸的有效剂量较小,且无腹泻等副作用,故一般作首选治疗。但熊去氧胆酸结合物在胆汁中的可溶度较鹅去氧胆酸低,Igimi 等曾推测用熊去氧胆酸治疗时可能出现糖-熊去氧胆酸沉淀物,后者又可能与钙结合,引起钙沉淀。作者报告6例在用熊去氧胆酸治疗时出现胆石钙化,并研究上述可能性。178例透光胆石病人分别用鹅去氧胆酸(122例)或熊去氧胆酸(56例)治疗6个月或更长的时间,全部病例均每隔6个月复查1次口服胆囊造影,胆石的钙化作用由放射学家评定,他们均不知病人是用何种胆酸治疗。结果用熊去氧胆酸治疗的56例有6例发生胆石
Chenodeoxycholic acid and ursodeoxycholic acid are to reduce the saturation index of cholesterol in bile, so that the dissolution of cholesterol stones due to the effective dose of ursodeoxycholic acid less, and no side effects such as diarrhea, it is generally preferred for treatment. However, the solubility of ursodeoxycholic acid conjugates in bile is lower than that of chenodeoxycholic acid and Igimi et al. Have speculated that a sugar-ursodeoxycholic acid precipitate may be present when treated with ursodeoxycholic acid, which in turn May be combined with calcium, causing calcium precipitation. The authors report 6 cases of gallstone calcification in the treatment of ursodeoxycholic acid and study the above-mentioned possibility. 178 cases of translucent gallstone patients were treated with chenodeoxycholic acid (122 cases) or ursodeoxycholic acid (56 cases) for 6 months or longer, all cases were reviewed every 6 months oral gallbladder Radiography and calcification of gallstones were evaluated by radiologists who did not know what bile acid was used by the patient. Results 56 cases of ursodeoxycholic acid treatment of 6 cases of gallstone occurred