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目的:探讨ACEI类药物致不良反应分析及临床合理用药。方法:接收在我院ACEI造成的不良反应患者一共有672例,对其不良反应给予分析研究。结果:672例病人当中使用药物当天的不良反应一共有42例,占总体的6.25%,用药第2天以后的不良反应一共有630例,占总体的93.75%,平均发生时间为16.5±21.3d。另外,卡托普利造成的不良反应一共有526例,占总体的78.27%,依那普利造成的不良反应一共有64例,占总体的9.25%;贝那普利造成的不良反应一共有46例,占总体的6.85%。不良反应大部分累及呼吸系统,一共有436例,占总体的64.88%。结论:ACEI导致的不良反应因素众多,应用的时候应该对也许出现的不良反应给予预测,进而使发生不良反应的几率明显降低,使治疗效果得到保障。
Objective: To investigate the adverse drug reactions caused by ACEIs and their clinical rational use. METHODS: A total of 672 patients who received ACEI-induced adverse reactions in our hospital were given an analysis of their adverse reactions. Results: A total of 42 adverse reactions were observed in 672 patients on the day of use of the drug, accounting for 6.25% of the total. There were 630 adverse reactions after the second day of treatment, accounting for 93.75% of the total. The average occurrence time was 16.5 ± 21.3 days . In addition, a total of 526 cases of adverse reactions caused by captopril, accounting for 78.27% of the total, the adverse reactions caused by enalapril a total of 64 cases, accounting for 9.25% of the overall; adverse reactions caused by benazapril a total of 46 cases, accounting for 6.85% of the total. Most adverse reactions involve the respiratory system, a total of 436 cases, accounting for 64.88% of the total. CONCLUSION: There are many adverse reactions caused by ACEI. When applied, the adverse reactions should be predicted, and the adverse reactions may be significantly reduced, thus ensuring the treatment effect.