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为探讨香烟烟对变态反应性疾病的影响，以香烟烟作为变应原，采用特异性体内皮肤试验测定了１６０６例变态反应性疾病患者对香烟烟的反应，并对香烟烟呈阳性反应与各种变态反应性疾病的关系以及与性别和年龄的关系进行了多元回归分析。结果表明，对香烟烟的皮试阳性的反应率为３４．６％（５５６例患者对香烟烟呈阳性反应），香烟烟的阳性反应与变应性疾病的发病有关，而与性别、年龄、病程、外周血白细胞计数和嗜酸性粒细胞计数相关性不大。对５８例香烟烟呈阳性反应的支气管哮喘患者，用乙酰甲胆碱做了气道激发试验，其结果为，激发后的最大肺活量（ＦＶＣ）、一秒钟用力呼气量（ＦＥＶ１）、最大呼气流速（ＰＥＦＲ）低于激发前。对２２３例香烟烟阳性反应者（其中支气管哮喘患者１８４例、变应性鼻炎８７例、过敏性皮肤病５２例），采用ＥＬＩＳＡ方法测定血清总ＩｇＥ，并与正常对照组比较，香烟反应的病人组血清总ＩｇＥ显著增高。由此可见，香烟烟可以引起变态反应性疾病。
In order to explore the impact of cigarette smoke on allergic diseases, cigarette smoke was used as an allergen, and specific in vivo skin tests were used to determine the response of 1606 patients with allergic diseases to cigarette smoke. The positive response to cigarette smoke and Multivariate regression analysis of the relationship between the type of allergic diseases and gender and age. The results showed that the skin test-positive response rate of cigarette smoke was 34.6% (556 patients were positive for cigarette smoke). The positive reaction of cigarette smoke was related to the onset of allergic diseases, but not to gender, age, Course of disease, peripheral blood leukocyte count and eosinophil count was not related. In 58 patients with bronchial asthma who had a positive response to cigarette smoke, methacholine was used to test airway irritation. The results were as follows: maximum vital capacity (FVC), forced expiratory volume per second (FEV1), maximum Expiratory flow (PEFR) was lower than before stimulation. Totally 223 cigarette smoke positive subjects (including 184 patients with bronchial asthma, 87 allergic rhinitis and 52 allergic skin diseases), the total serum IgE was measured by ELISA and compared with the normal control group Serum total IgE was significantly higher. Thus, cigarette smoke can cause allergic diseases.